Custom Peptides
Cayman Chemical SCH 202676hydrobromIde 10mg
A reversible inhibitor of both agonist and antagonist binding to diverse GPCRs; blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors with IC50 values of 0.1 to 1.8 µM
Cayman Chemical 2-OxoadIpIc AcId 10mg
An intermediate in the catabolism of L-tryptophan, L-lysine, and hydroxylysine; urinary excretion is increased in patients with α-ketoadipic aciduria
Cayman Chemical ProtodIoscIn 10mg
A natural steroidal saponin; cytotoxic to a range of cancer cells in vitro, including leukemia, colon cancer, and prostate cancer cells (GI50 ≤ 2 µM)
Cayman Chemical 3 5DIIodothyroacetIc AcId 10mg
A thyroid hormone derivative; inhibits copper-induced lipid peroxidation of LDL isolated from human plasma at 1 µM; increases urinary and fecal excretion of sterols and prevents high-fat diet-induced increases in liver lipid and cholesterol levels, in rats at 5 mg/100 g diet
Cayman Chemical Linolenoyl Ethanolamide 10mg
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids
Cayman Chemical 1 2DInonadecnoylsnglycero 10mg
A saturated phospholipid; has been used as a standard for the quantification of phosphatidylcholines in human synovial fluid; has been used to study dynamics of lipid bilayer phase transition
Cayman Chemical IsoscopoletIn 10mg
A coumarin with diverse biological activities and an active metabolite of scoparone; cytotoxic to A549, MCF-7, and HepG2 cells (IC50s = 5.25, 8.58, and 4.76 µM, respectively); active against S. aureus and E. coli in agar diffusion assays; inhibits 15-LO (IC50 = 15.1 µM); reduces paw thickness in a rat model of carrageenan-induced paw edema at 0.1 mg/kg
Cayman Chemical DarIfenacInhydrobromIde 10mg
A muscarinic M3 receptor antagonist (Ki = 0.76 nM); selective for M3 over M1, M2, M4, and M5 mAChRs (Kis = 7.08, 44.67, 45.71, and 9.33 nM, respectively); selectively inhibits contractions in isolated guinea pig ileum, bladder, and trachea (pA2s = 9.44, 8.66, and 8.7, respectively) over isolated rabbit vas deferens and isolated guinea pig atria (pA2s = 7.9 and 7.48, respectively); inhibits micturition pressure (ED50 = 0.089 mg/kg, i.v.), as well as micturition interval and volume in rats
Cayman Chemical 1 2DIoleoyl3ArachIdoylrac 10mg
A triacylglycerol; has been found in hazelnut, cashew, date seed, corn, sunflower, and soybean oils
Cayman Chemical 5 7DIchLRokynurenIc AcId 10mg
An NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay); selectively selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors; reduces NMDA-induced neurotoxicity in primary rat cortical neurons from 1 to 10 μM; reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner from 0.97-97 nmol; blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the PVN in anesthetized rabbits; increases social interaction time and time spent in the open arms of the elevated plus maze; disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm
ABclonal Technology Phospho-IRAK4-Thr345/Ser346 Rabbit pAb
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Cayman Chemical TrImetazIdInhydrochlorIde 10mg
An analytical reference standard categorized as a piperazine; has been detected as an AAF during anti-doping testing; intended for research and forensic applications
Cayman Chemical NaphthofluoresceIn 10mg
A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080
Cayman Chemical CH 275acetate 10mg
A cyclic peptide agonist of SST1 (IC50 = 30.9 nM for the human receptor); selective for SST1 over SST2, SST3, SST4, and SST5 (IC50s = >10,000, 345, >1,000, and >10,000 nM, respectively, for the human receptors); inhibits basal growth hormone secretion from primary mouse pituitary cells at 500 nM; inhibits glucose-induced increases in electrical activity without inducing membrane hyperpolarization in a whole-cell patch-clamp assay using MIN6 pancreatic β-cells at 100 nM