Custom Peptides
Cayman Chemical TaccalonlIde B 10mg
A taccalonolide with anticancer activity; induces microtubule bundling, formation of abnormal mitotic spindles, and cell cycle arrest at the G2/M phase in HeLa cells at 0.8 µM; decreases the proliferation of HeLa cells (IC50 = 190 nM)
Cayman Chemical JWH 210 6ethylnaphthyl 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical DemethoxycurcumIn 10mg
A natural demethoxy derivative of curcumin; suppresses proliferation in cancer cells at 50-100 μM; down-regulates p300 and inhibits LPS-induced iNOS expression
Cayman Chemical SynthetIc -KavaIn 10mg
A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM (+)-kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 UG/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)
Cayman Chemical 1 2DIpalmItoyl3Oleoylrac 10mg
A triacylglycerol; has been found in Apiaceae seed oils, lard, tallow, as well as palm oil, olein, and stearin; has been used as a substrate to determine the regioselectivity and substrate specificity of lipases from Geotrichum species
Cayman Chemical ZolIflodacIn 10mg
A fluoroquinolone antibiotic; inhibits bacterial DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation; active against 250 clinical isolates of N. gonorrhoeae, including XDR and MDR strains (MICs = 0.004-0.25 UG/ml); active against MRSA clinical isolates, as well as 10 clinical isolates EAch of C. trachomatis and C. pneumoniae (MIC50s = 0.125 and 0.5 UG/ml, respectively)
Cayman Chemical Demethylwedelolacton 10mg
A coumestan with diverse biological activities; reduces CCL4- and GaIN-induced cytotoxicity in rat hepatocytes in a dose-dependent manner; inhibits lethal and hemorrhagic activities of C. rhodostoma venom; inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells; decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice
Cayman Chemical 2Acetyl5tetrahydroxybutyl 10mg
An inhibitor of S1P lyase in vivo; not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation; reversibly increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs in mice at 50 UG/ml in drinking water
Cayman Chemical Aloe-emodIn 10mg
Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle; also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells
Cayman Chemical D L1ACtoxychavIcol ACTAt 10mg
A natural inhibitor of exportin 1, preventing the export of proteins from the nucleus; reduces several intracellular signaling pathways, including NF-κB, impacting inflammation, cancer, viral replication, and other processes
Cayman Chemical PIclIdenoson 10mg
An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively); reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 100 UG/kg; reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and the number of lung metastases in a model of metastatic murine melanoma; reduces colonic inflammatory cell infiltration and damage in a mouse model of DSS-induced colitis and in in IL-10-/- mice at 1 and 3 mg/kg
Cayman Chemical Solnum avcular Solasodn 10mg
An alkaloid with diverse biological activities; reduces glutamate-induced excitotoxicity in PC12 cells at 40 µM; inhibits cell invasion and migration of, as well as reverses TGF-β1-induced EMT in, HCT116 cells at 40 µM; reduces tumor growth and inhibits EMT in an HCT116 mouse xenograft model at 30 and 50 mg/kg; reduces carrageenan or arachidonic acid-induced paw edema at 75 mg/kg